Did you know....

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An Unresolved Drama

Although cancer in children is considered rare, it is the leading cause of death by disease among children in USA.

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Because One Is Too Many

Despite major treatment advances in recent decades, one in five children with cancer in the US will still not survive.

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The Cost Of Surviving 

More than 73% will have chronic health problems as a consequence of the treatments they receive.

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A Worldwide Problem

Childhood cancer does not discriminate. It is estimated that 80% of children diagnosed with cancer reside in developing countries.

 

The causes of most childhood cancers are still not known

Although only five percent of all cancers in children are caused by an inherited mutation, most of them are thought to develop as a result of gene mutations.

However, unlike many cancers in adults, gene mutations in childhood cancers are not strongly linked to life style or environmental factors. 

 

YEARS LOST

When a child dies of cancer there are 70 potential life years lost on average compared to 15 potential life years lost for adults

 

More than 95% of childhood cancer survivors will have a significant health related issue by the time they are 45 years of age

 
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Emotional

Changes in mood or behavior, depression, anxiety, social isolation, post traumatic stress disorder, and fear of recurrence 

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Physical

Hearing/vision loss, damage to endocrine system, dental problems, organ damage, musculoskeletal development disorders, secondary cancers, infertility

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Neurocognitive

Changes in attention span, concentration and comprehension, learning disabilities and memory problems, and executive functioning

 

When a child is diagnosed with cancer, it affects every family member and nearly every aspect of the family’s life

 
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The average family spends 40+ hours per week caring for their child while they are in active treatment

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Parents must take time off from work, or in many cases leave their job to care for their child

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The diagnosis of a child with cancer often times has a significant negative financial impact upon the family

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Siblings of children with cancer are at risk for emotional and behavioral difficulties, such as anxiety, depression, and post traumatic stress disorder

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Families often feel that only those who have lived through a similar experience can truly understand the difficulty of the journey

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Existing resources are only available during treatment or follow-up visits and
well-intentioned support initiatives by outside organizations are often temporary and insufficient

 
 

LACK OF RESOURCES

Unfortunately, financial investment for the development of pediatric cancer specific drugs remains dismal with only four pediatric specific drugs granted approval in the last 20 years versus 180 for adults

The development of pediatric cancer drugs faces several challenges

 
 
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Twelve types and multiple subtypes

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Low incidence rates

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Overcome regulatory complexity

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Access to expert researchers

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Need of pediatric formulations

 

Regulatory Incentives contribute to make investment on pediatric cancer drug development highly Capital Efficiency and Profitable

 

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